Carnosic acid use and function’s introduction

1. What are the uses and synthetic methods of rosemary extract carnosic acid？

Carnosic acid is a diterpenoid compound isolated from the leaves of rosemary. It is white or yellowish white powder, soluble in oil and alcohol, ethyl acetate, acetone, chloroform and other organic solvents, but insoluble in water. Carnosic acid is suitable for antioxidant of oil-soluble components. Used in sauces, pet food and feed, it has antioxidant and anti-aging effects. Strong weight loss and fat reduction effect; Treatment of cardiovascular diseases and anticancer effects.

Rosemarinus is a genus of labial herbs, native to southern European countries. It has been introduced and cultivated in Hunan, Guizhou, Hainan, Guangxi, Guangdong and other provinces and cities of China. It contains carnosic acid, rosinol, rosinol, carnosol, rosinol, isorosinol, rosinol and other active ingredients. Among them, the highly effective antioxidant substances are carnosic acid, rosinol and carnosol. Fat-soluble rosemary extract is light yellow to yellowish brown powder or brown paste, insoluble in water, soluble in ethanol and oil. Water soluble rosemary extract is a brown powder with a distinctive smell of rosemary. Heat resistance (stable at 200℃), uv Chemicalbook linear good, can effectively prevent oil oxidation.

Rosemary extracts can be divided into oil-soluble (antioxidant) and water-soluble (antioxidant and preservative), the former mainly carnosic acid, the latter mainly rosmarinol. Rosemary extract natural non-toxic, antioxidant effect is much higher than existing vitamin C, vitamin E, tea polyphenols and other natural antioxidants, is 2 to 4 times of synthetic antioxidants BHA, BHT, and its structure is stable, not easy to decompose, can withstand 190℃ to 240℃ high temperature. It completely overcomes the fatal weakness that most natural antioxidants such as vitamin C and tea polyphenols decompose at high temperature. Therefore, compared with other similar products, it has the advantage of more efficient and broad spectrum. The researchers found that the antioxidant activity of rosemary extract at 300mg/kg was equivalent to 200mg/kg gbha and greater than 100mg/kg tocopherol. Generally, its antioxidant capacity increases with the increase of adding amount, but high concentration can precipitate oil and discolor water-containing food. The antioxidant function of Rosemary mainly lies in its synergistic effect of quenching singlet oxygen, scavenging free radicals, chelating metal ions and organic acids.

2. What is carnosic acid rosemary pharmacological action

1) Studies on antibacterial effect show that carnosic acid has different degree of inhibitory effect on Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Saccharomyces hanson, and can be used as food preservatives.

2) Antioxidant effect Carnosic acid has good free radical scavenging and antioxidant effect. The DPPH and ABTS free radical scavenging capacity and iron reducing antioxidant capacity were stronger than those of VE, but weaker than those of SYNTHETIC antioxidant TBHQ. Its reducing ability is stronger than VE and TBHQ. Carnosic acid is fat soluble and can effectively inhibit the formation of peroxides and the decomposition of polyene fatty acids, thus prolonging the shelf life of oils. In addition, it was found that carnocaric acid can effectively remove oxygen free radicals and reduce the production of lipid peroxides in mouse liver cells, thus stabilizing cell membranes. Carnosic acid can also inhibit the oxidation reaction of Chemicalbook white of low density fatty eggs, which can effectively prevent the occurrence of atherosclerosis.

3) Other effects Studies have found that carnosic acid can inhibit the proliferation of HL-60 cells, which is expected to become a new drug for the treatment of hematological malignancies, cardiovascular diseases and anti-cancer. Kaloustian et al. introduced that rosemary extracts such as carnosic acid have certain therapeutic effects on heart disease and respiratory diseases, have antibacterial effects, and can also inhibit HIV infection. Ninomiya reports such as carnosic acid, rosemary extract, in addition to regulate the absorption of fat to control weight, so as to achieve the aim of reducing weight, also can treat inflammation, sore throat pain, maldigestion and prevent alzheimer's disease, diabetes, and promote the formation of nerve growth factor and so on.

3. What is carnosic acid used for?

1) Carnosic acid has antioxidant and anti-aging effects;

2) strong effect of weight loss and fat reduction;

3) Treatment of cardiovascular diseases and anticancer effects;

4) It can effectively prevent the oxidation of oil;

5) It can effectively prevent the occurrence of atherosclerosis;

6) It can treat inflammation, treat sore throat, treat indigestion, prevent Alzheimer's disease, treat diabetes, and promote the generation of nerve growth factor, etc.

7) Preservatives for food processing.

4. How much rosemary extract carnosic acid is in rosemary?

A DiamonsilR C18(200 mmx4.6 mm,5μm) column was used to determine the content of carnosic acid in Rosemary. Acetonitrile was used as mobile phase, and the ratio of acetonitrile to water was 60:40. The flow rate was 0.8 m L/min. The detection wavelength was 230 nm. Column temperature: 30 ℃; The results showed that carnosic acid ranged from 0. 0087 to 0. 0558 g/L at pH 4. 5~5.

5. What foods contain rosemary extract carnosic acid?

1) Carnosic acid is widely used as an antioxidant and preservative for edible oils, fried foods, oil-rich foods, baked foods, dairy products, meat, aquatic products and confectionery.

2) Used in sauces, pet food and feed, it has antioxidant and anti-aging effects; Strong weight loss and fat reduction effect; Treatment of cardiovascular diseases and anticancer effects.

Is rosemary a neuroprotective? Carnosic acid contains phenolic groups and is therefore often classified as polyphenols.