Fenugreek extract's advantages and precautions Fenugreek can help protect the liver from alcohol-induced damage, according to a 2007 report in the journal Cell Biology and Toxicology. This study investigated the effects of polyphenol extracts from Fenugreek seeds on collagen and liver lipids in rats with liver damage. Chronic alcoholics with fatty liver and fibrosis are characterized by accumulation of collagen.