Views: 0 Author: Site Editor Publish Time: 2022-08-31 Origin: Site
Peptides, as a food source of high-quality protein, have an important therapeutic effect on cancer patients who are unable to eat normally and suffer from digestive and absorption disorders. It also plays a very important role in nutritional support during the recovery of body function.
Bioactive peptides should be involved in many fields of the whole process of tumor disease: anti-tumor peptides, tumor peptide vaccines, cytokine mimicking peptides, diagnostic peptides, etc. Bioactive peptide is a general term for different peptides with different compositions and arrangements of amino acids, ranging from dipeptides to complex linear and circular structures.
Its main physiological function has kind of opioid activity, hormone and the role of hormone regulation, function of biological enzymes in the body has the adjusting and controlling, participate in immune regulation, growth and development, has the antithrombotic, high blood pressure, cholesterol, inhibition of bacteria and viruses, and the function of the oxidation and scavenging free radicals, improve transportation element absorption and minerals.
Cancer patients expect to take in sufficient nutrients from food, and this nutrient can be digested and absorbed by the body, so as to meet the requirements of modern daily life. Antioxidant, enhance immunity, resist weakness and strong musculoskeletal, each patient has individual requirements for bioactive peptide food, which also promotes the popularization of bioactive peptide food in clinical oncology nutrition. Bioactive peptides are structural and functional fragments of proteins, which possess strong biological activities and play a key role in maintaining and adjusting physiological activities such as nervous system, digestion and absorption, reproductive system, metabolism and circulatory system.
Bioactive peptides can be divided into plant and small animal sources. Plant-derived protein peptides are beneficial peptides produced by enzymatic hydrolysis of ribonucleotide or alcoholization of plant proteins. Protein peptides of small animal origin are animal proteins that are dissolved into healthy fragments according to the action of special ribonucleotides.
Because of their small molecular structures, they can be absorbed directly by the human body without digestion. It directly enters the small intestine, is absorbed by the small intestine, and then enters the human circulatory system to play biological functions. The absorption rate of peptide is synchronized with the infusion.
Bioactive peptides are preferentially absorbed by the human body in vivo, with the characteristics of active absorption or forced absorption, which is helpful for the absorption and utilization of cancer patients with poor digestive ability, nutritional deficiency and physical weakness. Its absorption does not need to consume human energy, does not need to increase the burden of digestive tract. Bioactive peptides have low sensitization and low osmotic concentration.
Bioactive peptide can immediately intervene the basic metabolism of body somatic cells, participate in the adjustment of various physiological functions of the human body, can give the body growth and development needs of nutritional elements, enhance immunity. Collagen peptides can promote articular cartilage regeneration and bone health by increasing extracellular matrix biosynthesis. Collagen peptides, which stimulate keratinocytes and fibroblasts, maintain the skin's defense barrier, and regulate proteins involved in immune responses.
In short, the absorption mechanism of bioactive peptides is superior to all substances, which is of great significance to the physiological health of tumor patients.
I. Anti-microbial, enhance immunity
Bioactive peptides such as antimicrobial peptides, interferons, interleukins and biodefensins can activate and regulate the immune response, significantly improve the proliferation of human peripheral blood lymphocytes, and thus play an anti-microbial role. Some oligopeptides and polypeptides can enhance hepatocyte viability, effectively adjust the function of lymphocyte subsets, and enhance humoral and cellular immunity.
II. Eliminate fatigue
Bioactive peptide is easy to be absorbed and utilized, when the body because of excessive consumption of nutrients, resulting in the internal environment imbalance in the body, each system function in an inefficient state and feel tired, take active peptide can quickly make the lack of active substances and nutrients in the body to supplement. So as to improve cell metabolism, restore the maladjusted internal environment, promote the coordinated work between various systems of the body, and achieve the purpose of eliminating fatigue;
III. Reduce blood pressure and blood lipids
Hypotensive peptide is a well-studied angiotensin converting enzyme inhibitor (ACEI), which has immune-promoting effects. Soybean peptide has a definite effect on reducing plasma cholesterol, and its main mechanism may be related to promoting cholesterol metabolism to produce bile acids.
IV. Anti oxidation action
Glutathione (GSH) is a dipeptide compound formed by condensation of glutamic acid, cysteine and glycine through peptide bonds. GSH molecular structure contains a reactive sulfhydryl group (a SH), easy to be oxidized deoxygenation, thus (GSH has a unique physiological function - antioxidant, scavenging free radicals, so that biological macromolecules, biofilm from damage;
V. Fall blood sugar
Bioactive peptides can timely supplement the nutritional elements of protein synthesis in the body, reduce the burden of insulin-secreting β cells, and play a good role in protecting β cells.
VI. antitumor
Bioactive peptides have many biological functions, such as immunomodulatory, antioxidant, etc., and they also show a certain prospect in clinical cancer treatment. Antitumor peptides derived from biological fermentation such as actinomycin D and bleomycin have been used in clinical practice for many years. Thymosin, interferon, interleukin, antimicrobial peptide and other immunoactive peptides have also been used in the treatment of solid tumors, lymphoma, prostate cancer, uterine cancer, colon cancer and other tumors. Low molecular peptide from oyster can inhibit the growth, division and proliferation of gastric adenocarcinoma and lung adenocarcinoma cells.
VII. analgesic
Opioid active peptides, such as enkephalin and other neuroactive peptides, such as growth hormone inhibitors, soothing kinin and thyroid stimulating hormone releasing hormone, play basic functions in the nervous system, such as analgesia, and enter the body through the digestive organs without any side effects, not easy to produce dependence.
VIII. Delay the weak
Because of the small molecular weight and compact structure of bioactive peptide, it can capture and eliminate excessive free radicals and harmful substances in the body to the maximum extent, inhibit the peroxidation of free radicals, repair cell function, maintain body vitality, reduce the occurrence of pigmentation, prevent and delay the appearance of senile plaques. Bioactive peptides can effectively enhance the immune function of the body, maintain normal cell metabolism and delay cell senescence, and prolong human life.
IX. Regulation of endocrine
X. In the bone tissue protein degradation of active peptide, the clinical trials for white scar wind, found that the cure rate of 70% or so, this kind of peptide material contains rich tyrosine and nutrients that help the melanin, and this kind of peptide has strong regulate endocrine function, for the low immune function and endocrine disorders caused by factors such as better treatment of vitiligo.
XI. Inhibit platelet aggregation and vasoconstriction
Active peptide can effectively promote the generation of prostacyclin in platelets, has a strong inhibitory effect on platelet aggregation and vasoconstriction, and can counteract the effect of thromboxane A2, effectively prevent the formation of thromboxane, and has an important role in the occurrence of cardiac and cerebrovascular diseases such as myocardial infarction and cerebral infarction.
XII. Promote mineral absorption
Casein phosphopeptides (CPPs) are peptides containing 25 to 37 amino acids that promote calcium and iron absorption. The distal ileum is the main place to absorb calcium and iron. When calcium in food passes through the stomach, it can form soluble calcium when it meets gastric acid. When it reaches the small intestine, the acidity decreases, and some calcium and iron form insoluble salts with phosphoric acid and are precipitated out, resulting in a decrease in absorption rate. CPPs can effectively form a soluble complex with calcium and iron ions, which can keep calcium and iron dissolved in the whole small intestinal environment, obviously delay and prevent the formation of insoluble phosphate crystals, and thus increase the absorption rate of calcium and iron in the distal ileum without vitamin D participation. CPPs are also carriers of many mineral elements such as iron, manganese, copper and selenium.
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