Does ursolic acid help with weight loss?
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Does ursolic acid help with weight loss?

Views: 0     Author: Site Editor     Publish Time: 2021-11-08      Origin: Site

Oleanolic acid is a clinically effective hepatoprotective drug, while ursolic acid is an isomer of oleanolic acid with very similarUrsolic-Acid buy-realclearbio three-dimensional structures and belongs to pentacyclic triterpene acids. , So the pharmacological effects are similar. Oleanolic acid and ursolic acid are the active ingredients contained in many vegetables, fruits and traditional Chinese medicines, and they are almost non-toxic. The author believes that oleanolic acid and ursolic acid are expected to be candidates for anti-metabolic syndrome. They have been reviewed from the perspectives of correcting abnormal glucose metabolism and anti-diabetics. This article reviews them from the aspects of correcting lipid metabolism, regulating blood lipids and anti-obesity. The pharmacological effects and mechanism of action provide a basis for the development of new drugs.

1. Ursolic Acid powder can regulate blood lipids

Giving normal rats ig oleanolic acid 50 mg/(kg·d) can reduce the amount of serum cholesterol and triacylglycerol (TG), and also have a tendency to reduce serum β-lipoprotein, but the dose is 20 mg/(kg · When d), there is no obvious effect. The above two doses of oleanolic acid can reduce the serum cholesterol (TC), TG, β-lipoprotein and free fatty acid content of rats and rabbits fed high-fat diet, and increase the amount of high-density lipoprotein cholesterol (HDL-C). And HDL-C/TC ratio. Oleanolic acid also prevents TC, low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) from increasing when preventing the formation of quail atherosclerosis, and increases the content of HDL-C and HDL- C/TC ratio. Yunoki et al. reported that ig 50 mg/(kg·d) oleanolic acid or ethanol extracts rich in oleanolic acid can significantly prevent the high-fat diet of 21% lard from increasing plasma TG and phospholipids in rats. Giving high-fat diet to type 2 diabetic rats ig oleanolic acid 10 mg/kg for 42 days can significantly reduce elevated blood glucose, serum TC, LDL-C and TG levels, and increase low HDL- C level.

Treating streptozotocin-induced diabetic rats with 100 and 200 mg/kg oleanolic acid extracted from Ligustrum lucidum for 40 days can significantly reduce serum TG, TC, and LDL-C levels while stimulating insulin secretion and lowering blood sugar. , Increase the level of HDL-C, but does not affect the levels of thyroxine and thyroid-stimulating hormone stimulating hormone in model rats. Oleanolic acid lowered blood sugar in alloxan-induced diabetic rats, while also significantly lowering serum TC, TG, LDL-C levels and increasing HDL-C levels. Give salt-sensitive and insulin resistant hereditary hypertensive rats ip oleanolic acid 60 mg/kg for 42 days. While preventing the occurrence of severe hypertension, it can lower blood sugar and anti-hyperlipidemia (reduce LDL and TG levels) effect. Giving Leprdb/db obese diabetic mice ip oleanolic acid 20 mg/kg for 14 days significantly reduced serum TC, TG, LDL, free fatty acid and blood glucose levels in mice.

2. Ursolic Acid can lower fat

It has been clinically observed that oleanolic acid can enhance the lipid-lowering effect of atorvastatin: 52 patients with primary hyperlipidemia po atorvastatin 20 mg/d, treatment course for 3 months, serum TC, LDL-C And TG decreased to (4.05±0.73), (2.81±0.54), (1.25±0.72) mmol/L, respectively. In 55 patients with primary hyperlipidemia, the above-mentioned dose of atorvastatin was added to 4 tablets of oleanolic acid, 3 times/d, for 3 months, and the above indicators were reduced to (3.53±0.34). , (2.22±0.41), (1.48±0.84) mmol/L, in which the effect of lowering serum TC and LDL-C was significantly enhanced by oleanolic acid. There is a domestic patent claiming that 10-100 mg of succinate half ester of po oleanolic acid per day can reduce the amount of TC and TG in the blood of patients with hyperlipidemia and increase the amount of HDL.