English Views: 0 Author: Site Editor Publish Time: 2021-10-25 Origin: Site
Rosmarinic acid has a very strong activity of scavenging free radicals in the body and an antioxidant effect. Studies have
shown that its mechanism of action is: rosmarinic acid competes with unsaturated fatty acids to combine with lipid peroxy groups to stop the chain reaction of lipid peroxidation and reduce the rate of lipid peroxidation, while rosmarinic acid is oxidized to Quinoid; marinic acid can inhibit the respiratory burst of neutrophils and inhibit the release of lysosomes by reducing the intracellular calcium ion concentration; inhibit the oxidation of low-density lipoprotein regulated by endothelial cells. The antioxidant effect of rosmarinic acid is related to its structure. Studies have shown that the o-diphenolic hydroxyl group is the material basis for the activity of scavenging free radicals. Moreover, the conjugated double bond at the C3 position has a synergistic effect.
Rosmarinic acid has antidepressant effects on animal models of depression. Experiments were performed on cell proliferation in the hippocampus of mice, and bromodeoxyuridine antibody was used for immunohistochemical analysis to explore its mechanism of action. It was found that in the rosmarinic acid treatment group, the labeled proliferation cells increased, combined with the forced swimming of the depression animal model Experiments have shown that rosmarinic acid at least partially proliferates through hippocampal gyrus cells and produces an antidepressant-like effect.
Rosmarinic acid has broad-spectrum antimicrobial activity and has inhibitory effects on bacteria and fungi. Rosmarinic acid has obvious inhibitory effect on bacteria such as Bacillus subtilis, Micrococcus luteus, Escherichia coli, Staphylococcus aureus and Rhizoctonia solani. It is scientifically found that rosmarinic acid can inhibit the growth and biofilm formation of Streptococcus caries and Streptococcus mutans, and reduce their glucosyltransferase activity, indicating that rosmarinic acid can be used for the prevention and treatment of oral diseases. Studies on the antibacterial mechanism of rosmarinic acid have shown that on the one hand, rosmarinic acid can increase the permeability of bacterial cell membranes, causing a large amount of sugar and protein to leak, and affect the normal metabolism of bacteria; on the other hand, it can also affect bacterial proteins. Metabolism, it also inhibits Taq DNA polymerase. Rosmarinic acid has antibacterial activity against Gram-negative bacteria Escherichia coli and Gram-positive bacteria Staphylococcus aureus, but Staphylococcus aureus is significantly more sensitive to rosmarinic acid than Escherichia coli.
(1) Bacteriostatic effect: Rosmarinic acid has a significant inhibitory effect on Bacillus subtilis, Yellow coccus luteus and Escherichia coli.
(2) Inhibiting fungi: Rosmarinic acid has inhibitory activity on the mycelial growth and spore germination of different plant pathogenic fungi.
(3) Inhibition of mold: Rosmarinic acid extracted from plants has an inhibitory effect on Phytophthora and its mold spores that cause soil-borne diseases, and effectively reduces the germination of zoospores.
(1) Anti-nephritis effect: Rosmarinic acid can inhibit the proliferation of glomerular mesangial cells and glomerular swelling.
(2) Anti-hepatitis effect: Rosmarinic acid can reduce the liver injury induced by lipopolysaccharide (LPS) and significantly inhibit the increase of plasma transaminase levels, which proves that the hepatoprotective effect of rosmarinic acid is through the elimination or reduction of superoxide Or oxidized nitrite is not produced by inhibiting TNF-α.
(3) Anti-pneumonia effect: Rosmarinic acid inhibits lung injury characterized by neutrophil detention and interstitial edema induced by diesel exhaust particles.
(4) Anti-arthritis effect: Rosmarinic acid can inhibit collagen-induced arthritis and significantly reduce the number of arthritis and affected joints.
(5) Anti-periodontitis effect: Rosmarinic acid can inhibit the formation of bacterial plaque, thereby preventing chronic gingivitis.
(6) Anti-dermatitis effect: Rosmarinic acid can relieve atopic dermatitis, also known as atopic eczema or atopic eczema.
(1) Anti-herpes virus: Rosmarinic acid shows special activity to type I and type II herpes simplex virus, and is an effective ingredient for controlling herpes. Its antiviral activity is in addition to inhibiting certain enzyme activities in the virus life cycle. , Can also quickly bind to the virus coat protein, thereby inactivating the virus.
(2) Anti-HIV: Rosmarinic acid can inhibit the activity of HIV-1 (human immunodeficiency virus 1) integrase.
(3) Anti-encephalitis virus: Rosmarinic acid can reduce the mortality of mice with Japanese encephalitis virus, significantly reduce the viral load, and make the virus difficult to spread.
Rosmarinic acid inhibits the expression of CCL11 and CCR3 by inhibiting the activity of β-kinase and the activation of related genes by nuclear factor kappa B, in order to achieve the purpose of anti-tumor.Rosmarinic acid can inhibit allergic inflammation induced by microallergens.Rosmarinic acid has a good free radical scavenging and antioxidant effect.
Rosmarinic acid can inhibit the formation of malondialdehyde in human platelets in vitro, with an IC50 value of 3.37 nmol/L, indicating that rosmarinic acid has anti-platelet aggregation activity.Rosmarinic acid can be used as a photoprotective agent to prevent radiation and anti-ultraviolet rays.
(1) Stabilizing effect on color (2) Inhibiting effect on hyaluronidase (3) Inhibiting effect on xanthine oxidase (4) Protecting liver(5) Inhibit angiogenesis (6) Prevent arteriosclerosis (7) Prevent memory damage (8) Use as cosmetics.
